Nucleotide sequence of the streptolysin O (SLO) gene: structural homologies between SLO and other membrane-damaging, thiol-activated toxins
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چکیده
منابع مشابه
Novel genomic rearrangement that affects expression of the Streptococcus pyogenes streptolysin O (slo) gene.
A RecA-independent chromosomal rearrangement in the upstream region of the streptolysin O (slo) gene of Streptococcus pyogenes which affects slo expression was identified. PCR analysis was used to demonstrate that this kind of rearrangement was found in several strains of different lineages. Chromosomal loci involved in the recombination were found to be 746 kb apart on the 1.85-Mb-long chromos...
متن کاملReduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation
Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome, leading to IL-1β secretion and pyroptosis. The structural determinants of pore-forming toxins required for NLRP3 activation remain unknown. Here, ...
متن کاملAutonomous expression of the slo gene of the bicistronic nga-slo operon of Streptococcus pyogenes.
A recent model for cytolysin-mediated translocation in Streptococcus pyogenes proposes that NAD-glycohydrolase is translocated through streptolysin O-generated pores into a host cell (J. Madden, N. Ruiz, and M. Caparon, Cell 104:143-152, 2001). This model also assumes that the NAD-glycohydrolase (nga) and streptolysin O (slo) genes that code for these products are organized in an operon-like st...
متن کاملSLO power calibration.
We present a method for calibrating the Scanning Laser Ophthalmoscope (SLO) that predicts radiant power at any of 256 grayscale values (gsv) and 12 polarized filter (polarizer) levels. Predicted power values, p(gsv), were determined by substitution into polynomials linearly transformed to old or new power at p(0) and p(255). This was compared with observed power values at 125 levels of attenuat...
متن کاملThe Sodium-Activated Potassium Channel Is Encoded by a Member of the Slo Gene Family
Na(+)-activated potassium channels (K(Na)) have been identified in cardiomyocytes and neurons where they may provide protection against ischemia. We now report that K(Na) is encoded by the rSlo2 gene (also called Slack), the mammalian ortholog of slo-2 in C. elegans. rSlo2, heterologously expressed, shares many properties of native K(Na) including activation by intracellular Na(+), high conduct...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1987
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.55.12.3228-3232.1987